ANTIBIOTIC SUSCEPTIBILITY OF STAPHYLOCOCCUS AUREUS FROM PATIENTS ATTENDING DALHATU ARAF SPECIALIST HOSPITAL, LAFIA, NIGERIA

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dc.contributor.authorNkene, I.H.
dc.contributor.authorNgwai, Y.B.
dc.contributor.authorUngokore, H.
dc.contributor.authorAtai, E.
dc.contributor.authorAbdullahi, A.M.
dc.contributor.authorAbah, E.J.
dc.contributor.authorAbdullahi, U.
dc.contributor.authorZakou, M.A.
dc.contributor.authorNgadda, N.J.
dc.date.accessioned2023-12-14T07:43:09Z
dc.date.available2023-12-14T07:43:09Z
dc.date.issued2015-04-04
dc.description.abstractStaphylococcus aureus is a major commensal and pathogen of humans. Study on the antibiotic susceptibility of S. aureus from different clinical samples of patients attending Dalhatu Araf Specialist Hospital Lafia, Nigeria was carried out. A total of 100 urine samples, 30 ear swabs, 40 blood samples, 60 wound swabs, 30 High Vaginal Swabs (HVS) and 25 Endocer\ncal swab samples were collected from Februaiy to April, 2014. Staphylococcus aureus was isolated using standard method and antibiotic susceptibility test was carried out in accordance with the guidelines of the Clinical and Laboratory Standards Institute (CLS1). The frequency of S. aureus irrespective of the source of the sample decreased in order: High vaginal swab (36.7%) > Endocen>ical swab (28.0%) > urine (14.0%) > Blood (7.5%) > Ear swab (3.3%) > Wound swab (3.3%). The S. aureus isolates were highly susceptible to gentamicin (94.7%), ofloxacin (68.4%), ciprofloxacin (SI.6%) and streptomycin (52.6%) nitrofuratoin (50.0%) and less susceptible to pefloxacin (47.4%), augmentin (34.2%), ampicillin (23.7%), cotrimoxazole and ceftriaxone (5.3%) respectively. Thirty six (94.7%) of isolates showed multiple antibiotic resistance (MAR); MAR indices of 0.2 and above. The high susceptibility of the isolates to ciprofloxacin and gentamicin is evidence that these antibiotics may be useful for the treatment of S. aureus infections in this localityen_US
dc.description.sponsorshipTETFUNDen_US
dc.identifier.citationNwoire A, Madubuko EF, Eze UA, Oti-Wilberforce RO, Azi SO, Ibiam GA, Egwu IH, Okereke EC, Obi IA (2013). Incidence of Staphylococcus aureus in clinical specimens in Federal Teaching Hospital, Abakaliki. Ebonyi State. J. Med. Med. Sci. 1(3): 43-46. Obiazi HAK, Nmorsi OPG, Ekundayo Ukwandu NCD (2007). Prevalence and antibiotic susceptibility pattern of Staphylococcus aureus from clinical isolates grown at 37 and 44 °C from Irrua, Nigeria. Afr. J. Microbiol. Res. 1(5): 57-60. Onanuga A, Oyi AR, Onaolapo JA (2005). Prevalence and susceptibility pattern of methicillin resistant Staphylococcus aureus isolates among healthy women in Zaria, Nigeria. Afr. J. Biotechnol; 4(11): 1321-1324. Onemu OS, Ophori EA (2013). Prevalence of Multi Drug Resistant Staphylococcus aureus in clinical specimens obtained from patients attending The University of Benin Teaching Hospital, Benin City, Nigeria. J. Natural Sci. Res. 3(5): 2224-3186. Orji I, Nworie A, Eze UA, Agberotimi IO, Okereke EC, Azi SO (2012). The prevalence and antimicrobial susceptibility profile of methicillin resistant Staphylococcus aureus isolates from clinical specimens in a Tertiary Hospital, South East Nigeria. Continental J.Pharm. Sci. 6(1): 23-29. Prescott M, Harley P, Klein A (2008). Chemotherapy. Microbiology 7th edition. McGraw-Hill, New York. Stanley CN, Ugboma HAA, Ibezim EC, Attama AA (2013). Susceptibility of Staphylococcus aureus and other staphylococcal infections in pregnant women attending Antenatal Clinic in a Tertiary Hospital in Port Harcourt, Nigeria. J. Infect. Dis. Ther. 2(1): 1-6. Chikere C.B, Chikere BO, Omoni VT (2008). Antibiogram of clinical isolates from hospital in Nigeria. African J. Biotechnol. 7(24): 4359-4363 CLSI (2007). Antimicrobial a AO. Performance Standard for Susceptibility Testing: Approved Standard M100-517. Clinical and Laboratory Standards Institute. Wayne. Egbuobi RC, Wachuku CK, Dike-Ndudim JN, Ogamaka IA, Okorie HM, Nwagbaraocha MA, Amadi JC, Egbuobi LN, Ereh JE (2014). Evaluation of antibacterial profile of methicillin resistant Staphylococcus (MRSA) isolated from hospitals in Imo State, Nigeria. Inti. J. Med.med. Sci. 6(2): 69-74. aureus Ehinmidu JO (2003). Antibiotics susceptibility patterns of urine bacterial isolates in Zaria, Nigeria. Trop. J. Pharm. Res. 2:223-228. Okonko IO, Soleye FA, Amusan TA, Ogun AA, Ogunnusi TA, Ejembi J (2009). Incidence of Multi-Drug Resistance (MDR) Organisms in Abeokuta. South western Nigeria. Global J. Pharmacol. 3(2): 69-80. Kolawole DO, Bisi-Johnson MA, Shittu AO (2005). Epidemiological analysis of clinical isolates Staphylococcus aureus in Ile-Ife, Nigeria. Pakistan J. Bio. Sci. 8(7): 1016-1020. Krumpermann PH (1983). Multiple Antibiotics Resistance Indexing of E. coli to Identify High Risks Sources of Fecal Contamination of Foods. Appl. Environ. Microbiol. 46: 165-170. Lowry FD (2003). Antimicrobial resistance: the example of Staphylococcus aureus. J. Clin. Invest. 111(9): 1265-1273. Prevalenceen_US
dc.identifier.urihttps://keffi.nsuk.edu.ng/handle/20.500.14448/5931
dc.language.isoenen_US
dc.publisherdepartment of microbiology, Nasarawa State University, Keffi.en_US
dc.subjectAntibiotics; Susceptibility; Staphylococcus aureus; Multiple Antibiotic Resistanceen_US
dc.titleANTIBIOTIC SUSCEPTIBILITY OF STAPHYLOCOCCUS AUREUS FROM PATIENTS ATTENDING DALHATU ARAF SPECIALIST HOSPITAL, LAFIA, NIGERIAen_US
dc.typeArticleen_US

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