Effect of leaf extracts of Carica papaya (Paw paw) and Pakia biglobosa (African locust bean) on some biochemical parameters of albino rats

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dc.contributor.authorEnemali, Okey Michael
dc.contributor.authorObaoji, Ikechukwu Kingsley
dc.contributor.authorOguazu, Chinenye Enoch
dc.contributor.authorHaruna, Sunday Gambo
dc.contributor.authorAsogwa, kelechi, Kingsley
dc.date.accessioned2023-12-14T06:37:54Z
dc.date.available2023-12-14T06:37:54Z
dc.date.issued2021-09-10
dc.description.abstractIn spite of the advances made in orthodox medicine, there has been an increasing interest in herbal medicine. The leaves of Carica papaya and Pakia biglobosa have been reported to contain lots of beneficial medicinal compounds, hence their use in the traditional prevention, management and treatment of ailments/diseases. In this study, the effect of varied concentrations of the ethanol leaf extract of the plants on some biochemical parameters of albino rats was assessed. The phytochemical compositions of the leaves were determined using established standard laboratory methods. Fifty four male Albino rats weighing between 150g-200g were randomly distributed into nine groups of six animals each. A daily single dose of 500mg/kg, 1000mg/kg, 1500mg/kg and 2000mg/kg body weight of either of the extracts was respectively, administered to the eight test groups for fourteen days. The control group was given only feed and water. Biochemical parameters such as the serum activities of Aspartate Aminotransferase, Alanine Aminotranferase and Alkaline phosphatase as well as the serum concentrations of Bilirubin, Albumin, HCO3-, Urea, Creatinine and Na+ were assessed. Result of the analyses showed that the administration of the extracts did not significantly raise the serum activity of ALT. The decreases in serum concentrations of Urea and increase in the concentration of HCO3- were directly proportional to the concentration of the extracts. It can be deduced from this study, that 500mg, 1000mg 1500mg and 2000mg/kg bw of either C. papaya or P. biglobosa did not elicit any marked hepatotoxicological or renotoxicological effect on the experimental animalsen_US
dc.identifier.citation[1] Truhaut R. Ecotoxicology: objectives, principles and perspectives. Ecotoxicology and Environmental Safety. 1977; 1: 151-173. [2] WHO. General Guidelines for Methodologies on Research and Evaluation of Traditional Medicine. 2000. [3] StuartXchange [http://www.stuartxchange.com/Malatalong.html]. Carica papaya Linn. 2013; seen on August 17, 2021 [4] Uddin B. Carica papaya Linn. 2013; seen on August 17, 2021. [5] Sop TK, Oldeland J, Bognounou F Ethnobotanical. knowledge and valuation of woody plants species: a comparative analysis of three ethnic groups from the sub-Sahel of Burkina Faso. Environmental Development and Sustainability. 2012; 14: 627–649. [6] Krishna KL, Paridhavi M, Jagruti, Patel A. Review on nutritional, medicinal and properties of papaya (Carica papaya Linn), Nat prod Rad. 2008; 7(4): 364-373. [7] Saba. “15 Best Benefits of Papaya Leaf Juice for Skin, Hair And Healt″. 2013. [8] Rochway. ‘Benefits of papaya leaf extract’.2013: seen on. 25 July 2021. [9] Haider. ‘15 Uses for Papaya Leaves’ - A Powerful Cure for Cancer’. 2013: seen on 25 July 2021. [10] Komolafe K, Akinmoladun AC, Komolafe TR, Olaleye MT, Akindahunsi AA, Rocha JBT. African locust bean (Parkia biglobosa, Jacq Benth) leaf extract affects mitochondrial redox chemistry and inhibits angiotensin converting enzyme in vitro. Clinical Phytoscience. 2017; 3: 19. [11] Shubham S, Mishra R, Gautam N, Nepal M, Kashyap N, Dutta K. “Phytochemical Analysis of Papaya Leaf Extract: Screening Test”. EC Dental Science 2019; 18(3): 485-490. [12] Pariyani R, Ismail IS, Azam AA, Abas F, Shaari K, Sulaiman MR. Phytochemical Screening and Acute Oral Toxicity Study of Java Tea Leaf Extracts. Biomedical Research International. 2015; 1-8. [13] Enemali MO, Udedi SC, Ubaoji KI, Haruna GS, Augustine E. Modulatory Effect of Leaf Extracts of Pterocarpus santalinoides Hook F. (Red Sandal Wood) on Acetaminophen-Induced Hepatotoxicity in Albino Rats. FUW Trends in Science & Technology Journal. 2019; 4(2): 366 – 371. [14] Obadoni BO, Ochuko PO. Phytochemical Studies and Comparative Efficacy of the crude Extracts of some Haemostatic Plants in Edo and Delta States of Nigeria. Global Journal of Pure and Applied Sciences. 2002; 8(2): 203-208.en_US
dc.identifier.urihttps://keffi.nsuk.edu.ng/handle/20.500.14448/5387
dc.language.isoenen_US
dc.publisherDepartment of Biochemistry, Nasarawa State University Keffien_US
dc.subjectCarica papaya; Pakia biglobosa; Aminotransferases; Hepatotoxicological; Renotoxicological; Biochemical parametersen_US
dc.titleEffect of leaf extracts of Carica papaya (Paw paw) and Pakia biglobosa (African locust bean) on some biochemical parameters of albino ratsen_US
dc.typeArticleen_US

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