Seroprevalence of Microsporidiosis in Inumunocompromised Patients in Kano, Nigeria

Microsporidial infections have- been, recognized as an increasingly important in immuncompromised patients, particularly those infected with Hiv/Aids. Stool Samples were examined for microsporidial spores by modified Giemsa staining technique and IgG antibodies to Microsporidia in Sora samples were detected by ELISA. Fcncal examination showed that M/192 (7.29%) oflilV/AIDS patients.hr.d microsporidia, comprising-IintcrQcytozoon biancusi 8/14 (57.-14%), Encephaljtozoon intestinalis 5/M (35.71 %) and mixed infection of.batli 1/14 (7.14%), while 0/50 of HIV-negative patients had microsporidia, The difference between them was not significant (x*> p>0.05). Enterocytozooh bicncusi Was detected, in 3/23 (13.04%) and 3/35 . (8.57% ) of TB/HIV/AIDS and TB/HIV-ncgativc patients. Serologioal evaluation showed that 22/168 (13.1.0%) of TIIV/ AIDS and 2/60 (3.33%) of HIV-negative patients were seropositive. There was n significant difference ; (X2* p<0.05) in Jreir infection rates. 0/30 of TB patients were seropositive. There wins a significant association • (p<0.05) bom con patients with Miorosporidiu and CD4 lymphocytes counts of $50 colls pL"1 and also with • diaiyhoea. This study aims at investigating Ihe occurrence of Mioronporidia in immunocompromised patients in order to provides baseline information on the status of Microsporidiosis in Kano-Nigeria. Detection of Microsporidia in immunocompromised patients has not been described previously in this area.