Effect of Sodium Bicarbonate on Haematological Parameters and Differential Cells in Plasmodium Berghei-infected Albino Mice

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dc.contributor.authorHaruna, Sunday Gambo
dc.contributor.authorEnemali, M.O.
dc.contributor.authorAchimugu, I.I.
dc.contributor.authorIsah, R.
dc.contributor.authorMiftahu, M.
dc.date.accessioned2023-12-14T06:37:55Z
dc.date.available2023-12-14T06:37:55Z
dc.date.issued2021-06-21
dc.description.abstractThe current study evaluated the hematological changes in albino mice following infection with P. berghei and treatment with sodium bicarbonate; an alkaline substance intended to alkalinize the pH in the parasite environment. Twenty albino mice were randomly divided into five groups of four mice each. Groups 3, 4 and 5 were the test groups and administered 84mg/kg b.w of sodium bicarbonate injection once, twice and thrice respectively. Groups 1 received dH20, group 2; only P. berghei. Three days later, hematological parameters and differential cells were analyzed. PCV was significantly (p<0.05) lower in groups 2(32.00±0.70), 3(34.00±0.70), 4(34.00±0.70), 5(33.00±0.70) compared to control (35.00±0.70). Haemoglobin decreased significantly (p<0.05) in group 5 (11.00±0.70) compared to control (11.80±0.70). WBC showed significant (p<0.05) increase in the test groups; 2(3600.00±70.71), 3(4600.00±70.71), 4(4800.00±70.71), 5 (4800.00±70.71) compared to control (3200.00±70.71). Platelets decreased significantly (p<0.05) in the test groups; 2(90.00±.70), 3(87.00±.70), 4(84.00±.70), 5(86.00±.70) compared to control (92.00±.70). The percentage neutrophils was significantly (p<0.05) higher in group 2(61.00±0.70), significantly (p<0.05) lower in groups 3(58.00±0.70), 4(57.00±0.70), 5(57.00±0.70) compared to control (60.00±0.70). Leucocytes increased significantly (p<0.05) in groups 2(36.00±0.70), 3(38.00±0.70), 4(38.00±0.70), 5(40.0±0.70) compared to control (32.00±0.70). Monocyte was significantly (p<0.05) lower in the test groups; 2(2.00±0.07), 3(2.00±0.07), 4(2.00±0.10) and 5(1.00±0.89) compared to control (4.00±0.07). Eosinophils decreased significantly (p<0.05) in group 2(1.00±0.35), increased significantly (p<0.05) in group 4(3.00±0.70) compared to control (2.00±0.70). Basophils were not detected in neither of the groups. This study revealed that sodium bicarbonate administered to albino mice infected with P. berghei caused the elevation of some hematological parameters and differential cells.en_US
dc.identifier.citation1. Kamble P, Bhagwat V, Trivedi DJ, Bargale A. Comparative study of free radical activity in Plasmodium falciparum and Plasmodium vivax malaria patients. Int J Pharm Bio Sci. 2011;2(4):99-102. 2. Akaninwor JO, Essien EB, Chikezie PC, Okpara RT. Haematologic and biochemical indices of Plasmodium falciparum infecteden_US
dc.identifier.urihttps://keffi.nsuk.edu.ng/handle/20.500.14448/5388
dc.language.isoenen_US
dc.publisherDepartment of Biochemistry, Nasarawa State University Keffien_US
dc.subjectDifferential cells; plasmodium berghei; sodium bicarbonate; extracellular fluid pH; Malaria.en_US
dc.titleEffect of Sodium Bicarbonate on Haematological Parameters and Differential Cells in Plasmodium Berghei-infected Albino Miceen_US
dc.typeArticleen_US

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