Evaluation of the Protective Effect of Citrullus lanatus (Water Melon) Fruit-Parts Extracts on the Liver of Acetaminophen-Intoxicated Albino Rats

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dc.contributor.authorEnemali, M.O.
dc.contributor.authorAsogwa, M.E.
dc.contributor.authorNweze, C.C.
dc.contributor.authorHaruna, Sunday Gambo
dc.contributor.authorIjeomah, A.U.
dc.date.accessioned2023-12-14T06:37:58Z
dc.date.available2023-12-14T06:37:58Z
dc.date.issued2020-10-29
dc.description.abstractThere is always the need to study the bioactive components present in the various parts of edible fruits. This will go a long way to providing an idea of its potential biological benefits when consumed. The current study evaluated the protective effect of C. lanatus fruit’s endocarp/exocarp, mesocarp and seed extracts on the liver of albino rats. The qualitative and quantitative phytochemical analysis was also done following standard methods. The albino rats were divided into nine groups of five per group and treated thus; group 1 (normal control), group 2, Acetaminophen (2 g/kg), group 3, 200 mg/kg silymarin + 2 g/kg Acetaminophen, group 4, 200 mg/kg mesocarp + 2 g/kg Acetaminophen, group 5, 400 mg/kg, group 6, 200 mg/kg exocarp, group 7, 400 mg/kg exocarp, group 8, 200 mg/kg seeds, group 9, 400 mg/kg seeds. The pre-treatment with the extracts lasted for 14 days then acetaminophen administered. The rats were sacrificed after 48 hours of intoxication. Results showed the presence of alkaloids, phenolics, Tannins, steroids and terpenoids and glycosides while saponins and flavonoids were not detected in the endocarp. In the mesocarp, glycosides, phenolics, steroids and terpenoids and tannins were present while Saponins and flavonoids were not detected. Seed extract showed the presence of alkaloids, flavonoids, phenolics, tannins, steroids and terpenoids. Glycosides and saponins were not detected. The activities of AST, ALT and ALP were significantly (p < 0.05) increased in group 2 (55.80 ± 3.11, 20.80 ± .84 and 27.00 ± 1.22 respectively) when compared to the normal control group (group 1) (32.00 ± 2.12, 9.00 ± 1.00 and 19.80 ± 4.49 respectively). The administration of the extracts (group 4, 5, 6, 7, 8 and 9) led to a significant decrease in the serum activities of AST (51.40 ± 1.14, 48.60 ± 7.57, 39.20 ± 1.79, 48.00 ± 1.73, 51.00 ± 0.00 and 47.00 ± 2.74) and ALT (10.20 ± 1.30, 11.20 ± 1.30, 17.20 ± 2.77, 20.00 ± 0.71, 17.60 ± 0.55 and 18.20 ± 1.64) when compared with the acetaminophen group (group 2). Photomicrograph images showed normal liver morphology in the control groups 1 and 3, 200 mg/kg mesocarp and 400 mg/kg seed extract administered groups, indicating that the two extract doses better protected the liver against damage occasioned by acetaminophenen_US
dc.identifier.citation[1] Bailey, L.H. (1930) Three Discussions in Cucurbitaceae. Gentes Herbarum, 2, 175-186. [2] Chomicki, G. and Renner, S.S. (2014) Watermelon Origin Solved with Molecular Phylogenetics Including Linnaean Material: Another Example of Museomics. New Phytologist , 205, 526-532. https://doi.org/10.1111/nph.13163 [3] Maynard, D. and Donald, N. (2012) 6: Cucumbers, Melons and Watermelons. In: Kiple, K.F. and Ornelas, K.C., Eds., The Cambridge World History of Food, Part 2, Medical History , 46, Cambridge University Press, Cambridge, 267-270. [4] Erhirhie, E.O. and Ekene, N.E. (2013) Medicinal Values on Citrullus lanatus (Watermelon): Pharmacological Review. International Journal of Research in Pharmaceutical and Biomedical Sciences , 4, 1305-1312. [5] Charoensiri, R., Kongkachuichai, R., Suknicom, S. and Sungpuag, P. (2009) Beta- Carotene, Lycopene, and Alpha-Tocopherol Contents of Selected Thai Fruits. Food Chemistry , 113, 202-207. https://doi.org/10.1016/j.foodchem.2008.07.074 [6] Altaş, S., Kızıl, G., Kızıl, M., Ketani, A. and Haris, P.I. (2011) Protective Effect of Diyarbakır Watermelon Juice on Carbon Tetrachloride-Induced Toxicity in Rats. Food and Chemical Toxicology , 49, 2433-2438. https://doi.org/10.1016/j.fct.2011.06.064en_US
dc.identifier.urihttps://keffi.nsuk.edu.ng/handle/20.500.14448/5393
dc.language.isoenen_US
dc.publisherDepartment of Biochemistry, Nasarawa State University Keffien_US
dc.subjectCitrullus lanatus , Acetaminophen, Mesocarp, Endocarp, Seeds, Liveren_US
dc.titleEvaluation of the Protective Effect of Citrullus lanatus (Water Melon) Fruit-Parts Extracts on the Liver of Acetaminophen-Intoxicated Albino Ratsen_US
dc.typeArticleen_US

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