Genotype distribution of hepatitis B virus in a subset of infected young people in Central Nigeria

Files

HBV Genotypes among nsuk students.pdf (991.95 KB)

Date

2019-09-15

Authors

Journal Title

Journal ISSN

Volume Title

Publisher

DEPARTMENT OF MICROBIOLOGY, NASARAWA STATE UNIVERSITY, KEFFI.

Abstract

Ten genotypes (A–J) of hepatitis B virus (HBV) with distinct geographical distribution have been identified as a result of the high degree of genetic heterogeneity of the virus; with Nigeria being the most likely origin of genotype E. HBV genotypes play critical roles in response to antiviral therapy. However, the circulating genotypes of the virus in an HBVendemic Nigeria are not well understood. In this study, we evaluated the genotypes of HBV amongst a subset of infected young people in Central Nigeria. A total of 350 sera were analysed. All the samples that tested positive for both HBsAg and HBeAg were genotyped by PCR using type-specific primers. A total of 29 cases (8.3%) were both HBsAg and HBeAg positive. Of these, 4 (13.8%) were genotype A (HBV/A), 10 (34.5%) genotype B (HBV/B) and 13 (44.8%) genotype E (HBV/E); suggesting that genotype E was predominant. Additionally, 2 (6.9%) had mixed infection with genotypes B and E. Age and gender were not associated with genotype distribution ( P > 0.05 ) . This is the first report of genotype B as a circulating variant in Nigeria. These findings have critical national and regional implications for the epidemiology of the virus, vaccination, antiviral therapy and clinical outcomes.

Description

Keywords

Hepatitis B HBV genotype Nigeria

Citation

[1] G.R. Pennap, B.V. Oti, A.G. Alaribe, S.A. Ajegena, P.R. Galleh, Seroprevalence of hepatitis B and C viruses among HIV infected patients accessing healthcare in Federal Medical Centre, Keffi, Nigeria, J. Adv. Microbiol. 3 (4) (2017) 1–6, doi: 10.9734/JAMB/2017/34284 . [2] M.P. Adoga , E.B. Banwat , J.C. Forbi , L. Nimzing , C.R. Pam , S.D. Gyar , Y.A. Agabi , S.M. Agwale , Human immunonodeficiency virus, hepatitis B virus and hepatitis C virus: sero-prevalence, co-infection and risk factors among prison inmates in Nasarawa State, Nigeria, J. Infect. Dev. Ctries. 3 (7) (2009) 539–547 .[3] J.C. Forbi, G. Vaughan, M.A. Purdy, D.S. Campo, G.L. Xia, L.M. Ganova-Raeva, S. Ramachandran, H. Thai, Y.E. Khudyakov, Epidemic history and evolutionary dynamics of hepatitis B virus infection in two remote communities in rural Nigeria, PLoS One 5 (7) (2010) e11615, doi: 10.1371/journal.pone. 0011615 . [4] M.P. Adoga , S.D. Gyar , S. Pechulano , O.D. Bashayi , S.E. Emiasegen , T. Zungwe , O.H. Iperepolu , C. Agupugo , S.M. Agwale , Hepatitis B virus infections in apparently healthy urban Nigerians: data from pre-vaccination tests, J. Infect. Dev. Ctries. 4 (6) (2010) 397–400 . [5] Z.Y. Lado , C.C. Ogbaga , O.F. Nwagbara , Epidemiology of hepatitis B viral infection among students and non-teaching (casual) staff of Nile University of Nigeria: a 2017 study, J. Pub. Health Epidemiol. 10 (3) (2018) 77–86 . [6] M.P. Adoga , G. Pennap , B.O. Akande , J.P. Mairiga , S. Pechulano , S.M. Agwale , Evaluation of a recombinant DNA hepatitis B vaccine in a vaccinated Nigerian population, J. Infect. Dev. Ctries. 4 (11) (2010) 740–744 .

URI

https://keffi.nsuk.edu.ng/handle/20.500.14448/5924

Collections

Articles