Browsing by Author "Adoga, P. Moses"

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    Genotype distribution of hepatitis B virus in a subset of infected young people in Central Nigeria
    (DEPARTMENT OF MICROBIOLOGY, NASARAWA STATE UNIVERSITY, KEFFI., 2019-09-15) Pennap, Grace Rinmecit; Haruna, Isa Mohammed; Oti, B. Victor; Adoga, P. Moses
    Ten genotypes (A–J) of hepatitis B virus (HBV) with distinct geographical distribution have been identified as a result of the high degree of genetic heterogeneity of the virus; with Nigeria being the most likely origin of genotype E. HBV genotypes play critical roles in response to antiviral therapy. However, the circulating genotypes of the virus in an HBVendemic Nigeria are not well understood. In this study, we evaluated the genotypes of HBV amongst a subset of infected young people in Central Nigeria. A total of 350 sera were analysed. All the samples that tested positive for both HBsAg and HBeAg were genotyped by PCR using type-specific primers. A total of 29 cases (8.3%) were both HBsAg and HBeAg positive. Of these, 4 (13.8%) were genotype A (HBV/A), 10 (34.5%) genotype B (HBV/B) and 13 (44.8%) genotype E (HBV/E); suggesting that genotype E was predominant. Additionally, 2 (6.9%) had mixed infection with genotypes B and E. Age and gender were not associated with genotype distribution ( P > 0.05 ) . This is the first report of genotype B as a circulating variant in Nigeria. These findings have critical national and regional implications for the epidemiology of the virus, vaccination, antiviral therapy and clinical outcomes.
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    Markers of hepatitis B virus infection in a subset of young people in central Nigeria
    (DEPARTMENT OF MICROBIOLOGY, NASARAWA STATE UNIVERSITY, KEFFI., 2019-05-23) Haruna, Isa Mohammed; Pennap, G.R.I.; Oti, B. Victor; Adoga, P. Moses
    Hepatitis B virus (HBV) is 50–100 times more infectious than HIV, and hepatitis B is endemic in Nigeria. In this study, we evaluated the serologic markers of HBV infection and associated socio-demographic factors in a subset of young people in Central Nigeria . Blood samples were collected from 350 consenting newly admitted students of the 2016/2017 academic session of Nasarawa State University, and their socio-demographic information obtained using structured questionnaires. The sera were analysed for HBsAg, HBsAb, HBcAb, HBeAg and HBeAb using a 5-panel HBV profiling diagnostic kits (Qingdad High Top Biotech Co. Ltd, Hangzhou, China). Data was analysed using Smith’s Statistical Package (version 2.80, California, USA); and test of significance performed at 95% confidence limit with P values ≤0.05 considered significant. Of the 350 participants, 157 (44.9%) were male and 193 (55.1%) were female. Overall, 34 (9.7%) had HBsAg, 134 (38.3%) had HBsAb, 98 (28.0%) had HBcAb, 13 (3.7%) had HBeAg and 16 (4.6%) had HBeAb. Gender distribution showed that 20 (12.7%), 78 (49.7%), 59 (37.6%), 9 (5.7%) and 11 (7.0%) of male subjects had HBsAg, HBsAb, HBcAb, HBeAg and HBeAb respectively. Among female subjects, the distribution of HBsAg, HBsAb, HBcAb, HBeAg and HBeAb was 14 (7.3%), 56 (29.0%), 39 (20.2%), 4 (2.1%) and 5 (2.6%), respectively. Being male, unmarried and histories of alcohol consumption, blood transfusion, sharing of sharp objects and multiple sex partners were significant predictors of infection ( p ˂ 0.05). This study reveals high prevalence of HBV and risk of transmission in the apparently healthy freshmen. Our findings have critical implications for intervention initiatives especially among students and youths.