Ibrahim, T.Olonitola, O. S2023-12-142023-12-142016-04-09Abdullahi, M., Olonitola, O. S., Umoh, V. J., and Inabo I. H. (2015). Antibacterial resistance profile and PCR detection of antibiotic resistance genes in Salmonella serovars isolated from blood samples of hospitalized subjects in Kano, North West Nigeria. British Microbiology Research Journal 5(3): 245-256.. Agada, G. O., Abdullahi, I. O., Aminu, M., Odugbo, M., Chollom, S. C. (2014). Prevalence and antibiotic susceptibility profile of Salmonella Isolates from commercial poultry and poultry farm-handlers in Jos, Plateau State. British Microbiology Research Journal, 4(4): 462-479. Agidigbi, T. S., Jemiseye, O. T., and Idowu, P. A (2016). Multidrug resistant Salmonella enterica strains in south western Nigeria: prevalence and susceptibility to ceftriaxone. Journal of Advances in Medical and Pharmaceutical Sciences. 6(4): 1-7. Akinyemi, K. O., Phillip, W., Beyer, W., Bohm, R. (2007). Invitro antimicrobial susceptibility patterns of Salmonella enteric serovars and emergence of Salmonella phage type DT071 in a suspected community-associated outbreak in Lagos, Nigeria. Journal of Infectious Disease in Developing Countries, 1(1): 48-54. Akyala, I. A., Manasseh, K,, Haruna, Y., Tanimu, .H., Ashefo, D. and Anzene, J. S. (2013). Non-Salmonella Bacteremia Among Seropositive Hiv Patients, Attending Three Tertiary Hospital In Nasarawa State, Nigeria. Journal of Natural Science and Research. 3: 5.https://keffi.nsuk.edu.ng/handle/20.500.14448/6190Antibiotic resistance is a growing phenomenom in contemporary medicine and has emerged as a serious public health concern of the 21st century in particular as it pertains to pathogenic organisms. A total of three hundred and ninety (390) stool samples of HIV seropositive individuals were screened for the presence of Salmonella using enrichment (selenite F broth) and selective (MCA,SSA and XLD) media. Biochemical identification tests were carried out using both the conventional and the Microgen Bioproduct identification system. Polyclonal antisera were employed for the slide agglutination tests. The standardized Kirby-Bauer technique was used for the antibiotic susceptibility testing where thirteen antibiotics were used. Three (3) Salmonella typhi and eleven (11) Salmonella typhimurium were isolated. Furthermore, 73% of Salmonella typhimurium isolated were resistant to ampicillin and Tetracycline respectively whereas all of the Salmonella Typhi were resistant to the antibiotics. Reduced susceptibility was observed with ciprofloxacin, pefloxacin, septrin and streptomycin for Salmonella typhimurium while no resistance was encountered for Salmonella typhi. An increased susceptibility of Salmonella typhimurium to chloramphenicol was observed but Salmonella typhi was completely susceptible. Ceftriaxone, Ofloxacin, Sparfloxacin and Amoxicillin showed effective antimicrobial activity against the Salmonella serovars and are therefore suggested as the drugs of choice for the treatment of Salmonellosis infections.enAntimicrobial drugs, Chloramphenicol, Kirby-Bauer technique, Salmonella serovars, Susceptibility.Article