Ajoku, G.A.Ibrahim, K.Ijele, I.Ezeunala, M.Abdulrahim, M.E.Izebe, K.S.Oladosu, P.Ngwai, Y.B.Mohammed, S.B.Ya'aba, Y.Oladepo, D.Inyang, U.S.2023-12-142023-12-142006-05-11Ajoku, G.A. & E.tel (2006) SCREENING FOR ANTIMICROBIAL POTENTIAL OF THE CRUDE METH ANOLIC EXTRACT OF THE LEAVES OF PHYSALIS ANGULATA L. AND ITS FRACTIONShttps://keffi.nsuk.edu.ng/handle/20.500.14448/5797The methanolic crude extract of die leaves of Physalis angulata was screened for its antimicrobial poten. against Escherichia coli. Pseudomonas aeroginosa. Staphylococcus aureus. Candida albicans, Bacillus spp and Proteus spp using agar dilution method. Surface streaking was employed as the method of inoculation of die organisms on the agar. The crude extract showed significant activity against Bacillus spp and Proteus spp at 2.5mg/ml. On separation of the crude extract, ten out of sixteen fractions of the crude extract exhibited significant activity against Candida albicans and Proteus spp with MIC between 0:2 5 m g/ml - 0.5mg/mL Seven fractions had MIC between 0.25mg/ml- 0.5mg/ml. against Escherichia coli, while five fractions had MIC between 0.5ml - LOmg/mi against Bacillus spp. Five fractions showed activity against Pseudomonas aeroginosa and Staphylococcus aureus at MIC between l.Omg/ml - 2.0mg/mI. Phytochcmical screening of the crude extract revealed the presence of tannins, phlabotannins, phenols. Steroids, saponins and terpenes. It is interesting that some fractions of the methanolic crude extract showed activity against Pseudomonas aeroginosa among other microorganisms, This point to the fact that this study may lead to the development of a new antimicrobial to add to the few existing to combat difficult infections due to Pseudomonas aeroginosa which is resistant to most commonly used antimicrobials.enPhysalis angulata (mullaca). antimicrobial activity, phytochemical screening, minimum inhibitory concentration, methanolic extract.Article