Sotolu, A. O.Yakubu, O. S.2023-12-112023-12-112014-04-13Garcia, D., Escalante, M., Delgado, R., Ubeira, F. M., Sanmartin, M. L. & Leiro, J. (2003). Antihelminthic and anti allergic activity of Mangifera indica Lp Hytother Res. 17: 1203-1208. Guillaume, J., Kaushik, S., Bergot, P. & Metailler, R. (1999). Nutrition and feeding of fish and crustaceans. Praxis publishing, Chichester, United Kingdom. Pp. 81-109. Heidarieh, M., Mirvaghefi, A.R., Sepahi, A., Sheikhzadeh, N., Shahbazfar, A. A. & Akbari, M. (2013). Effects of Dietaiy Aloe Vera on Growth Performance, Skin and Gastrointestine Morphology in Rainbow Trout (Oncorhynchus mykiss). Turk. J. of Fish, and Aquatic Sci. 13: 367-373. Iwu, M.M. & Igboko, A.O. (1982). Constituent of Garcinia kola seeds. J.Nat. Prod. Lloydia. 45: 650-651. Kim, S. E. & Lee, K. J. (2009). Dietary protein requirement of juvenile tiger puffer (Takifugu rubripes). Aqua. 287,219-222. Millward, D. J. (1989). The nutritional regulation of muscle growth and protein turnover. Aqua. 79,1, NRC (1989). National Research Council Recommended Dietary Allowances 10th edition. National Academy Press; Washington D. C. USA. Rey-V'azquez, G. & Guerrero, G.A. (2007). Characterization of blood cells and hematological parameters in Cichlasoma dimerus (Teleostei, Perciformes). Tissue and Cell 39 (2007): 151-160. Sotolu, A. O. & Faturoti, E. O. (2010): Growth haematology of Clarias gariepinus (Burchell, 1822) fed varying inclusions of Leucaena leucocephala seed meal based-diets. Revista UDO Agricola 9 (4): 979- 985. Steel, R. G., Tome, J. H. & Dickey, D. A. (1997). Principles and procedures of statistics. A biometric approach, 3rd Ed. McGraw-Hill Co. Inc., New York. Yano, T. (1996). The non specific immune system: humoral defence In: Iwama, G.and Nakanishi, T. (eds). The fish immune system organism, pathogen and environment: 106- 159. Academic Press, San Diego. Zapata, A., Diez, B. Cejalvo, T., Frias, CG. & Cortes, A. (2006). Ontogeny of the immune system of fish. Fish and Shellfish Immunol. 20:126-136https://keffi.nsuk.edu.ng/handle/20.500.14448/3101ArticleOne hundred and fifty African catfish (mean weight, 673.30-813.30g) were divided equally among five groups in triplicate. Each group is a treatment of graded bitter kola (Garcinia kola) inclusion level for ensuring healthy fish production. Five diets (42% crude protein) containing varying levels of powdered whole seed of G. kola at 0.00, 0.25, 0.50, 0.75 and J.OOg/kg were prepared as treatments Tl- T5 respectively. All groups were fed respective treatment-based-diets for forty-two (42) days during which data on body weight and blood parameters were recorded. There were significant differences (P < 0.05) in the growth performance and nutrient utilization efficiency. Fish fed 0.25g/kg G. kola inclusion (T2) had the best weight gain and specific growth rate with relative inferior feed conversion ratio and protein efficiency ratio to T4 and 5 (p>0.05). Values of Pack Cell Volume (PCV), Haemoglobin Concentration (Hb) and Red Blood Cell (RBC) count were highest in T2 but they all decreased with increasing levels of G. kola inclusion. White Blood Cells (WBC) count generally decreased from Tl to T5. The bacterial load of the culture medium decreased accordingly with increasing G. kola inclusion in tanks which may be as a result of the antimicrobial effect of G. kola whole seeds. Inclusion of G. kola whole seeds at 0.25g/kg in catfish diet is recommended to ensure successful fish production.enCatfish, Garcinia kola, Antimicrobial, Successful Fish Production, Feed additiveArticle