Namadina, M.M.Shawai, R.S.Abdulrazak, M.H.Makin, T.Y.Muhammad, Hassan SaniAdamu, M.M.Abdullahi, N.A.2023-12-142023-12-142020-12-11Ajali, U., Chukwurah, B.K. (2004).Antimicrobial activity of Securidaca longipedunculata. Phytomedicine 11: 701-705 Andrade, Jr, G., Dalvi, T., Silva, C., Lopes, K., Alonso, A. and Hermes, M. (2005).The antioxidant effect of tannic acid on the in vitro copper-mediated formation of free radicals. Journal of Archives of Biochemistry and Biophysics, 437(1), 1-9. Bouchet, N., Barrier, L. and Fauconneau, B. (1998).Radical scavenging activity and antioxidant properties of tannins from Guiera senegalensis(Combretaceae).Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 12(3), 159-162. Chen, Y., Miao, Y. and Huang, L. (2014). “Antioxidant activities of saponins extracted from Radix trichosanthis: An In vivo and In-vitro evaluation,” BMC Complementary and Alternative Medicine, 14, 86. Chung, T., Wong, Y., Wei, I., Huang, W. and Lin, Y. (1998).Tannins and human health: a review. Journal of Critical reviews in food science and nutrition, 38(6), 421-464. Daniel, D. and Dluya, T. (2016).In vitro Biochemical assessments of methanol stem bark extracts of FicussycomorusPlant. Jordan Journal of Biological Sciences, 9(1). 63 – 68. Degollado, J., Yolo, T. and Santiago, A. (2014).Hypoglycemic effect and in vitro antioxidant activity of the dichloromethane fraction from the leaves of Ficusodorata(B.)International Journal of Research and Development in Pharmacy and Life Sciences3 (5) 1163-1173. Evans, W. C. (2009). Trease and Evans pharmacognosy’‟, 16th edition, W. B. Saunders Ltd., London, 10 – 11. Evans W.C. (1989). Trease and Evan’s Pharmacognosy.13th Edn. Bailliere Tindall, London.https://keffi.nsuk.edu.ng/handle/20.500.14448/6108The study aimed at evaluating phytochemical constituents, analgesic and antioxidant properties of root extract of Securidaca longipedunculata. Phytochemical constituents were screened using standard methods. Acetic acid induced writhing test in mice were used to evaluate the analgesic effect, while antioxidant activity was evaluated using the standard method. The extract was found to contain carbohydrate, tannins, glycosides, steroid and triterpenes were detected in both hexane, ethyl acetate and methanolic extracts. Alkaloid, flavonoid, saponins, phenol and anthraquinones were detected in the ethyl acetate and methanolic extract but absent in hexane extract. The extract and standard significantly decreased the number of writhes caused by acetic acid. The effects observed at 25mg/kg more than that of 50mg/kg and 100 mg/kg of the extract. The effect observed in 50mg/kg and 100 mg/kg group was comparable to that of the standard. The median lethal dose in rats was found to be above 5000 mg/kg. The half maximal percentage inhibition (IC50) of S. longipedunculata ethyl acetate and n-butanol root fraction was 0.042 μg/ml and 2.77 μg/ml, respectively. The two fractions also scavenged DPPH in a dose dependent manner. The extract was found to possess constituents that may be associated with its analgesic and antioxidant effects observed at doses tested. The present study therefore recommends a further screening to enhance their ultimate application in management of analgesic and oxidative stress-related disordersenAntioxidant, Phytochemical constituents, Securidaca longipedunculataArticle