Egbu, Chukwunonso HenryHaruna, Isa MohammedPennap, Grace Rinmecit2023-12-142023-12-142020-12-101. World Health Organization. Hepatitis B; 2018. Accessed on 15 October, 2020 Available:https://www.who.int/newsroom/ fact-sheets/detail/hepatitis-b 2. Oti BV, Pennap GR, Ngari HR. HBsAg and anti-HCV prevalence among pregnant women accessing antenatal care in a tertiary healthcare facility in Central Nigeria. Hepatology and Pancreatic Science. 2018;2-110–113. 3. Thio CL, Hawkins, CA. Hepatitis b virus and hepatitis delta virus, Mandell, Douglas and Bennett’s Principles and Practice of Infectious Diseases, 8th ed., Elsevier Inc, 2014;1815–1839. 4. World Health Organization. Hepatitis B fact sheet; 2015. Accessed on 10 October, 2020. Available:http://www.who.int/mediacenter/f actsheets/fs328/en/ 5. Mbaawuaga EM, Iroegba CU, Ike AC. Hepatitis B virus serological patterns in Benue State, Nigeria. Open Journal of Medical Microbiology. 2014;4:1-10https://keffi.nsuk.edu.ng/handle/20.500.14448/5928Aims: This study was conducted to evaluate the patterns of hepatitis B virus infection serologic markers among blood donors at a tertiary healthcare Facility in Central Nigeria Study Design: The study was a cross sectional study. Place and Duration of Study: Keffi, Nasarawa State, between January and October, 2018. Methodology: Blood sample (3 ml) was collected from each of the 400 consenting blood donors at Federal Medical Centre, Keffi, Nasarawa State and their socio-demographic information obtained using structured questionnaires. The sera were screened for HBV infection serologic markers (HBsAg, HBsAb, HBeAg, HBeAb and HBcAb) using HBV-5 rapid panel test kit (CTK Biotech. Inc. San Diego, USA). Data collected were analysed using Smith’s Statistical Package (version 2.8, California, USA) and P value of ≤ 0.05 was considered statistically significant. Results: Majority of the 400 blood donors screened were males (391/400) and aged 25-34 years (203/400). Of these, 31(7.8%) were positive for HBsAg, 113(28.3%) for HBsAb, 11(2.8%) for HBeAg, 18(4.5%) for HBeAb and 78(19.5%) for HBcAb. Analysi;s of these sero-markers indicated that 1.5% of the donors had chronic infection with high viral replication, 1.2% had acute infection with high viral replication, 4.5% were carriers with low viral replication, 0.7% had occult infection, 0.5% were recently vaccinated, 15.5% were immuned due to successful vaccination, 12.8% were immuned as a result of natural previous exposure to the virus while 63.3% were not exposed to the virus. Age and gender were not associated with HBV infection in this study (P > 0.05). However there was statistically significant difference between age and gender with rate of HBcAb (P < 0.05). Conclusion: We confirmed the presence occult HBV infection among prospective blood donors in the study area. Hence, HBV profiling for routine screening of blood donors should be made mandatory to avoid transfusion-associated hepatitis B virus infection.enHepatitis B virus; infection; seromarkers; blood donors; Central Nigeria.Article