Christiana, Oketa2023-12-142023-12-142019-12-08A PROJECT SUBMITTED TO SCHOOL OF POSTGRADUATE STUDIES, NASARAWA STATE UNIVERSITY, KEFFI, IN PARTIAL FULFILMENT OF THE REQUIRMENTS FOR AWARD OF POSTGRADUATE DIPLOMA IN MICROBIOLOGY.https://keffi.nsuk.edu.ng/handle/20.500.14448/5984Methicillin-Resistant Staphylococcus aureus (MRSA) have been reported as a resistant and the common cause of both hospital and community acquired infections. Study on the Minimum Inhibitory Cncentrations (MICs) of levofloxacin and ciprofloxacin was carried out. The MICs of levofloxacin and ciprofloxacin against MRSA was carried out using agar dilution method as earlier described by Clinical and Laboratory Standard Institute (CLSI). The MICs of levofloxacin for 50% (MIC50) and 90% (MIC90) of MRSA isolates were <.0.25pg/ml and 14.97pg/ml. While that of ciprofloxacin for 50% (MIC50) and 90% (MIC90) of MRSA isolates were 2.441 pg/ml and 14.91 pg/ml respectively. The isolates were more susceptible to levofloxacin 81.25% but less susceptible to ciprofloxacin 43.75%. Levofloxacin may be a drug of choice for treatment of infections caused by MRSA. In vivo studies on evaluation of minimum inhibitory concentrations (MICs) of levofloxacin and ciprofloxacin against the MRSA should be carried out.enThesis