Eghieye,O.M.Nkene, I.H.Abimiku, R.H.Ngwai, Y.B.Ibrahim, Y.Parom, S.K.2023-12-142023-12-142020-08-05[1] R. M. Akova, F. Baquero, J. Carlet,M. Cavaleri, S. Coenen, J. Cohen, D. Findlay, I. Gyssens, O. E. Heuer, G. Kahlmeter, H. Kruse, R. Laxminarayan, E. Liébana, L. López-Cerero, A. MacGowan, M. Martins, J. Rodríguez-Baño, J. M. Rolain, C. Segovia, B. Sigauque, E. Tacconelli, E. Wellington, J. Vila, Corrigendum to “The global Threat of Antimicrobial Resistance: Science for Intervention” New Microbes New Infect, 2015, 6: pp 22–29 [2] J. Ma, Z. Zeng, Z. Chen, X. Xu, X. Wang, Y. Deng, D. Lü, L. Huang, Y. Zhang, J. Liu, High Prevalence of Plasmid-mediated Quinolone Resistance Determinants qnr, aac(6′)-Ib-cr, and qepA among ceftiofur-resistant Enterobacteriaceae isolates from companion and food-producing animals. Antimicrob Agents Chemother, 2009, 53: pp 519–524. [3] L. S. Redgrave, S. B. Sutton, M. A. Webber, L. J. Piddock. Fluoroquinolone Resistance: Mechanisms, Impact on Bacteria, and Role in Evolutionary Success. Trends Microbiol, 2014, 22: pp 438– 445. [4] K. J. Aldred, R. J. Kerns, N. Osheroff. Biochemistry Mar 18; 2014, 53(10): pp 1565–1574. [5] M. Röderova, D.Halova, I. Papousek, M. Dolejska,M. Masarikova,V. Hanulik, V. Pudova, P. Broz, M. Htoutou-Sedlakova, P. Sauer, J. Bardon, A. Cizek, M. Kolar, I. Literak, Characteristics of Quinolone Resistance in Escherichia coli Isolates from Humans, Animals, and the Environment in the Czech Republic. Front Microbiol, 2016, 7: pp 2147. [6] J. C. Yeh, D. Y. Lo, S. K. Chang, C. C. Chou, H. C. Kuo, Prevalence of Plasmid-mediated Quinolone Resistance in Escherichia coli Isolated from Diseased Animals in Taiwan. J VetMed Sci, 2017, 79(4): pp 730– 735.https://keffi.nsuk.edu.ng/handle/20.500.14448/5911Urinary tract infections (UTIs) caused by Escherichia coli (E. coli) is common worldwide; and its successful treatment using antibiotics is limited by acquisition of resistance by the bacteria. This study investigated the occurrence of plasmid-mediated quinolone resistance (PMQR) genes in ciprofloxacinresistant E. coli from urine of patients with suspected cases of UTIs attending Garki Hospital Abuja (GHA), Nigeria. A total of 8 confirmed ciprofloxacinresistant E. coli was screened for carriage of PMQR genes using polymerase chain reaction (PCR) method. The occurrences of the PMQR genes detected were in the order: aac-(6′)-Ib-cr (87.5%) > qnrB (50.0%) > qnrS (37.5%) > oqxAB (12.5%) > qnrA(0.0%). qnrB and qnrS did not exist alone, but in combination with other genes; aac-(6′)-Ib-cr existed both alone and in combination with others; themost prevalent patterns of existence were aac-(6′)- Ib-cr alone and aac-(6′)-Ib-cr + qnrB + qnrS at 25.0% each. This study has shown that the ciprofloxacin-resistant E. coli harbored aac-(6′)-Ib-cr, qnrB, qnrS and oqxAB PMQR genes, with aac-(6′)-Ib-cr being themost prevalent. The genes were present either alone or in combination with one another. This has implication for the clinical application of fluoroquinolones to treat UTI in the study location and environs.enAntibiotic, Escherichia coli, hospital, molecular, plasmid-mediated.Article