Bamidele, Titilayo O.Enemali, Okey MichaelIsaiah, NyshirHaruna, Sunday Gambo2023-12-142023-12-142020-12-31Achagiotis, C., et al. (1990). Alcohol drinking, food and fluid intakes and body weight gain in rats. Physiol. Behav. 47(4) 679-84. Adeneye, A.A. and Benabo, A.S. (2008). Protective effect of the aqueous extract of Phyllantus amarus on gentamicin and acetaminopheme induced nephrotoxic rats. Journal of ethno- pharmacology. 118:318-323. Adeneye, A.A., Olagunju, J.A., BanjO, A.A.F., Abdul, S.F., Sanusi, O.A., Sanni, O.O., Osarodion B.A. and Shonoiki, O.E. (2009). The aqueous seed extract of Carica papaya Linn prevents carbontetrachloride induced hepatotoxicity in rats. 2(2):19-32. Bamidele, T. O., Enemali, M. O. and Ijeomah, A. U. (2018) Hepatoprotective Activity of Ethanol Extract of Purple Onion Bulb (Allium cepa Linn) on CCl4-Induced Hepatotoxicity in Wistar Rats. FUW Trends in Science & Technology Journal 3(1); 149 – 152 www.ftstjournal.com. Bancroft, J. D., Suvarna, K. S. and Christopher, L. (2013). Bancroft’s Theory and Practice of Histological Techniques. Seventh ed. Churchill Livingstone-Elsevier. Da-Silva, V.A., Da-Silva, J.B., Gismondi, R.A.O.C. and Rebello, G.P. (2000). Ethanol improves lactatio n outcome in malnourished rats. Nutri- tional Neuroscience, 3: 277-282. Dharmarathna, S.L., Wickramasinghe, S., Waduge, R.N., Rajapakse, R.P., Kularatne, S.A. and Halim, S.Z. (2013) Does Carica papaya leaf-extract increase the platelet count? An experimental study in a murine model. Asian Pac J Trop Biomed, 3(9): 720-724. Enemali, M. O. and Udedi, S. C. (2018) Comparative evaluation of the protective effect of leaf extracts of Vernonia amygdalina (bitter leaf) and Ocimum canum (curry) on acetaminophen induced acute liver toxicity. Journal of Pharmacognosy and Phytotherapy 10 (7): 116 – 125. http://www.academicjournals.org/JPP - DOI: 10.5897/JPP2018.0497 Enemali,M.O., Udedi, S C., Ubaoji, K. I., Haruna, G. S. and Augustine, E. (2019).Modulatory Effect of Leaf Extracts of Pterocarpus santalinoides Hook F. (Red Sandal Wood) on Acetaminophen-Induced Hepatotoxicity in Albino Rats. FUW Trends in Science & Technology Journal 4(2); 366 – 371 www.ftstjournal.com. Harborne, J.B. (1973). Phytochemical Methods. Chapman andHall Ltd., London pp.49-188. Ighodaro, M.O. and Omole, J.O. (2012). Ethaonol induced hepatotoxicity in male wistar rats: Efects of aqueous leaf extract of Ocimum gratissimum. Journal of Medicine and Medical Science. 3(8):499-505. Jaiswal, P., Kumar, P., Singh, V.K. and Singh, D.K. (2010). Carica papaya Linn: A Potential source for various health problems. Journal of Pharmacy Research 3(5): 998-1003. Jensen, T., Retterstøl, L.J., Sandset, P.M., Godal, H.C. and Skjønsberg, O.H. (2006). A daily glass of red wine induces a prolonged reduction in plasma viscosity: a randomized controlled Blood coagulation & fibrinolysis. 17(6):471– 6.https://keffi.nsuk.edu.ng/handle/20.500.14448/5419Plants being a reservoir of bioactive compounds with pharmaceutical potentials have been the source of raw materials for pharmaceutical industries. The present research investigated the phytochemical constituents and the ameliorating effects of aqueous seed extract of Carica. papaya on ethanol-induced hepatotoxicity in albino rats. Thirty rats weighing between 200g – 280g were randomly distributed into five groups of six rats each. Various doses of 5g/kg/12hr of 20% ethanol per day and (100, 200, 400) mg/kg/day oral doses of the extract were administered for 14 days, to groups C, D and E respectively. Group A took neither ethanol nor extract, while group B was given alcohol without the extract. The animals were sacrificed and biochemical parameters determined following standard protocols. Results showed that the significant increase (p<0.05) in serum activities of alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and altered electrolytes concentration were reversed by the extract. The hepatic architecture was also preserved. It can be concluded that the extract has potential protective effects on the liver and kidney against ethanol-induced toxicity.enEthanol, Hepatotoxicity, Carica papaya, PhytochemicalsArticle