SYNTHESIS OF 3-METHYL 2-(Tert-utyldimethylsiloxy) FURAN B. Y. Makama
Date
2011-07-05
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Department of Chemistry, Nasarawa State University Keffi
Abstract
Protection of 3-mcthyl-2-(5H)-furanone to 3-niethyl 2-(Tert-butyldimethyIsiloxy)furan was accomplished with an excellent yield of78%, which provided a neiu possible route for synthesizing \Y-butenolides. This concise method that started with abromobutyrolactone could lead to key methodologies towards the synthesis of fused bicycl cilac tones compou n ds
Description
Keywords
3-methyl-2-(5 H)-fura none, 3-methyl 2-(tert-butyldimethylsiloxy)furan, | Y-bu tenolides
Citation
Andricux, J.; Barton, H. R.; Partin, H. J. 1977. Rhodiumcatalysed isomerisation of some unsaturated organic substrates. J. Chem. Soc., Perkin Trans, 1:359-363. Amarego, W. L. F.; Perrin, D. D. 1998. Purification of Laboratory Chemicals, Pergamon Press Oxford. Feringa, B. L.; De Lange Bolhuis, B. V. 1989. Asymmetric 1, 4-additions to 5-alkoxy-2 (5H)- furanonesenantioselectlve synthesis and absolute configuration determination of □- amino-Q-butyrolactones and amino diols. Tetrahedron, 45:6799 - 6818.