SYNTHESIS OF 3-METHYL 2-(Tert-utyldimethylsiloxy) FURAN B. Y. Makama

Date

2011-07-05

Journal Title

Journal ISSN

Volume Title

Publisher

Department of Chemistry, Nasarawa State University Keffi

Abstract

Protection of 3-mcthyl-2-(5H)-furanone to 3-niethyl 2-(Tert-butyldimethyIsiloxy)furan was accomplished with an excellent yield of78%, which provided a neiu possible route for synthesizing \Y-butenolides. This concise method that started with abromobutyrolactone could lead to key methodologies towards the synthesis of fused bicycl cilac tones compou n ds

Description

Keywords

3-methyl-2-(5 H)-fura none, 3-methyl 2-(tert-butyldimethylsiloxy)furan, | Y-bu tenolides

Citation

Andricux, J.; Barton, H. R.; Partin, H. J. 1977. Rhodiumcatalysed isomerisation of some unsaturated organic substrates. J. Chem. Soc., Perkin Trans, 1:359-363. Amarego, W. L. F.; Perrin, D. D. 1998. Purification of Laboratory Chemicals, Pergamon Press Oxford. Feringa, B. L.; De Lange Bolhuis, B. V. 1989. Asymmetric 1, 4-additions to 5-alkoxy-2 (5H)- furanonesenantioselectlve synthesis and absolute configuration determination of □- amino-Q-butyrolactones and amino diols. Tetrahedron, 45:6799 - 6818.

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