SYNTHESIS AND FLUORESCENCE CHARACTERISTICS OF 2-A-ANILINOPURINE, 2-/VPIPERIDINOPURINE, 6-A-ANILINOPURINE AND 6-A-PIPERIDINOPURINE

dc.contributor.authorAbdullah, Z.
dc.contributor.authorBakar, M. A. A
dc.contributor.authorIdris, A. Mohd
dc.date.accessioned2023-12-14T06:54:12Z
dc.date.available2023-12-14T06:54:12Z
dc.date.issued2008-08-01
dc.description.abstract2-Fluoropurine was prepared from 2aminopurine through a diazotization reaction, followed by treatment with Jluoroboric acid. 2-Aminopurine was obtained from a series of reactions, using 5-nitrouracil as the starting material. 2- N-Piperidino and 2- N-anilinopurines were obtained by treating 2-fluoropurine with piperidine and aniline respectively. 6-N-Piperidino and 6-N-anilinopurines were obtained by treating 6-chloropurine with piperidine and aniline. Fluorescence studies were carried out in various solvents and maximum fluorescence was observed in 75% ethanol. 2- Aminopurine showed the highest fluorescence intensity, followed by 2-N-anilino and 2-N-piperidinopurines. 6- Substituted purines showed stronger fluorescence intensities compared to 2-substitutedpurinesen_US
dc.identifier.citationAbdullah Z., 1989. Synthesis and fluorescence studies of selected heterocycles, PhD. Thesis, Queen Mary & Westfield College, Uni. of London. Kiburis J.; Lister J. H. 1971. 'Nucleophilic displacement of the trimethylammino-group as a new route to fluoropurine', J. Chem Soc (C), 381. Abdullah, Z. Bakar, M. A. A. 2006 '2-Substituted purines: Synthesis and fluorescence characteristics Int. Journal of Chem. Sci., 4(2): 241-247. Lakowicz, J.R 1999. Principle of Fluorescence, Kluwer Acedemic/Plenum Publisher. Montgomery J. A. 1956. 'Synthesis of potential anticancer agents. I Chloropurine, JAmer. Soc., 78:1928. Abdullah, Z., Mohd Tahir N., Abas M. R., Low B. K.; Aiyub Z. 2004. 'Synthesis and fluorescence characteristic of 2-alkyl and aminopyrimidines', Molecules, 9:520-26. 2 - a r y 1 Montgomery J. A.; Hewson J. 1960. Synthesis of fluorinatedpurines,. J. Amer. Chem. Soc., 82: 463. Albert A.; Brown D. J. 1954. Purine studies. Part 1, Stability to acid and alkali. Solubility comparison within pterdines,. J. Chem Soc., 2060. Whittaker N. 1951. 'Pyrimidines: Syntheses of aminopyrimidines',/. Chem Soc.,1565. Robins R.K. 1962 'Potential purine antagonist.XXXIII. Synthesis of chloropurines',/y4p/?/ Chem,, 432-436. Brown D. J., Albert, A.; Cheeseman G. 1951. Pteridine Studies: Part 1, Pteridine, and 2- and 4- amino and 2- and 4- hydroxypteridine,. J. Chem Soc. ,474. Beaman A. G.; Caputo G.A.; London E. 2003. Cumulative effects of amino acids substitutions and hydrophobic mismatch upon the transmembrane stability and comformation of hydrophobic alpha-helices’, Biochemisty 25: 42(11), 3275-85en_US
dc.identifier.urihttps://keffi.nsuk.edu.ng/handle/20.500.14448/5539
dc.language.isoenen_US
dc.publisherFACULTY OF NATURAL AND APPLIED SCIENCE NASARAWA STATE UNIVERSITY, KEFFI.en_US
dc.subjectPiperidinopurine, anilinopurine, synthesis, fluorescenceen_US
dc.titleSYNTHESIS AND FLUORESCENCE CHARACTERISTICS OF 2-A-ANILINOPURINE, 2-/VPIPERIDINOPURINE, 6-A-ANILINOPURINE AND 6-A-PIPERIDINOPURINEen_US
dc.typeArticleen_US

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