Browsing by Author "Makin, T.Y."

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    PHYTOCHEMICAL, ANALGESIC AND ANTIOXIDANT ACTIVITIES OF Securidaca longipedunculata ROOT
    (Department of Plant Science and Biotechnology, Nasarawa State University Keffi, 2020-12-11) Namadina, M.M.; Shawai, R.S.; Abdulrazak, M.H.; Makin, T.Y.; Muhammad, Hassan Sani; Adamu, M.M.; Abdullahi, N.A.
    The study aimed at evaluating phytochemical constituents, analgesic and antioxidant properties of root extract of Securidaca longipedunculata. Phytochemical constituents were screened using standard methods. Acetic acid induced writhing test in mice were used to evaluate the analgesic effect, while antioxidant activity was evaluated using the standard method. The extract was found to contain carbohydrate, tannins, glycosides, steroid and triterpenes were detected in both hexane, ethyl acetate and methanolic extracts. Alkaloid, flavonoid, saponins, phenol and anthraquinones were detected in the ethyl acetate and methanolic extract but absent in hexane extract. The extract and standard significantly decreased the number of writhes caused by acetic acid. The effects observed at 25mg/kg more than that of 50mg/kg and 100 mg/kg of the extract. The effect observed in 50mg/kg and 100 mg/kg group was comparable to that of the standard. The median lethal dose in rats was found to be above 5000 mg/kg. The half maximal percentage inhibition (IC50) of S. longipedunculata ethyl acetate and n-butanol root fraction was 0.042 μg/ml and 2.77 μg/ml, respectively. The two fractions also scavenged DPPH in a dose dependent manner. The extract was found to possess constituents that may be associated with its analgesic and antioxidant effects observed at doses tested. The present study therefore recommends a further screening to enhance their ultimate application in management of analgesic and oxidative stress-related disorders