Browsing by Author "Enemali, Okey Michael"

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    Amelioration of ethanol-induced hepatotoxicity by aqueous seed extract of pawpaw (Carica papaya L.) in albino rats
    (Department of Biochemistry, Nasarawa State University Keffi, 2020-12-31) Bamidele, Titilayo O.; Enemali, Okey Michael; Isaiah, Nyshir; Haruna, Sunday Gambo
    Plants being a reservoir of bioactive compounds with pharmaceutical potentials have been the source of raw materials for pharmaceutical industries. The present research investigated the phytochemical constituents and the ameliorating effects of aqueous seed extract of Carica. papaya on ethanol-induced hepatotoxicity in albino rats. Thirty rats weighing between 200g – 280g were randomly distributed into five groups of six rats each. Various doses of 5g/kg/12hr of 20% ethanol per day and (100, 200, 400) mg/kg/day oral doses of the extract were administered for 14 days, to groups C, D and E respectively. Group A took neither ethanol nor extract, while group B was given alcohol without the extract. The animals were sacrificed and biochemical parameters determined following standard protocols. Results showed that the significant increase (p<0.05) in serum activities of alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and altered electrolytes concentration were reversed by the extract. The hepatic architecture was also preserved. It can be concluded that the extract has potential protective effects on the liver and kidney against ethanol-induced toxicity.
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    Effect of leaf extracts of Carica papaya (Paw paw) and Pakia biglobosa (African locust bean) on some biochemical parameters of albino rats
    (Department of Biochemistry, Nasarawa State University Keffi, 2021-09-10) Enemali, Okey Michael; Obaoji, Ikechukwu Kingsley; Oguazu, Chinenye Enoch; Haruna, Sunday Gambo; Asogwa, kelechi, Kingsley
    In spite of the advances made in orthodox medicine, there has been an increasing interest in herbal medicine. The leaves of Carica papaya and Pakia biglobosa have been reported to contain lots of beneficial medicinal compounds, hence their use in the traditional prevention, management and treatment of ailments/diseases. In this study, the effect of varied concentrations of the ethanol leaf extract of the plants on some biochemical parameters of albino rats was assessed. The phytochemical compositions of the leaves were determined using established standard laboratory methods. Fifty four male Albino rats weighing between 150g-200g were randomly distributed into nine groups of six animals each. A daily single dose of 500mg/kg, 1000mg/kg, 1500mg/kg and 2000mg/kg body weight of either of the extracts was respectively, administered to the eight test groups for fourteen days. The control group was given only feed and water. Biochemical parameters such as the serum activities of Aspartate Aminotransferase, Alanine Aminotranferase and Alkaline phosphatase as well as the serum concentrations of Bilirubin, Albumin, HCO3-, Urea, Creatinine and Na+ were assessed. Result of the analyses showed that the administration of the extracts did not significantly raise the serum activity of ALT. The decreases in serum concentrations of Urea and increase in the concentration of HCO3- were directly proportional to the concentration of the extracts. It can be deduced from this study, that 500mg, 1000mg 1500mg and 2000mg/kg bw of either C. papaya or P. biglobosa did not elicit any marked hepatotoxicological or renotoxicological effect on the experimental animals